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Welcome to a unique and excitingly different reality in tissue repair: tissue regeneration with AlloDerm as an excellent biological framework that supports nature's own regenerative healing process.
AlloDerm Defined
Core technology: AlloDerm is an acellular dermal matrix derived from donated human skin tissue supplied by US AATB-compliant tissue banks utilizing the standards of the American Association of Tissue Banks (AATB) and Food and Drug Administration's (FDA) requirements. Since AlloDerm is regarded as minimally processed and not significantly changed in structure from the natural material, the FDA has classified it as banked human tissue.
AlloDerm begins with natural tissue
Human skin consists of both epidermis and dermis. In nature, the dermis contains a framework of biochemical and structural components that allow it to regenerate and replace itself continually throughout life. This complex natural framework consists of a three-dimensional arrangement of:
- Proteins with a structurally intact basement membrane
- Intact collagen fibers and bundles to support tissue ingrowth
- Intact elastin filaments for biomechanical integrity
- Hyaluronan and proteoglycans
How is AlloDerm modified from natural tissue?
When AlloDerm is prepared, the human donor tissue undergoes a multi-step proprietary process that removes both the epidermis and the cells that can lead to tissue rejection and graft failure, without damaging the matrix.
Once the dermal tissue has been decellularized, the final step is preservation. The processed tissue matrix is preserved with a patented freeze-drying process that prevents damaging ice crystals from forming.
What components are left after this process?
The cells responsible for immune response and graft rejection are removed. What remains is a matrix or framework of the natural biological components, which allows the body to mount its own tissue regeneration process.
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