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AlloDerm Benefits
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The AlloDerm process delivers a safe and clinically efficacious tissue matrix for use in abdominal wall and hernia repair. The benefits of AlloDerm include:
- STRONG AND INTACT - As strong as synthetics, yet far more pliable; superior suture retention strength when compared to other commercially available biological materials; proprietary process results in an intact matrix.1,2
- RESISTS INFECTION - Supports rapid revascularization, which can minimize the risk of infection; supports revascularization through existing vascular channels and new blood vessel formation; allows white blood cells to migrate to the site.3,4,5,6,7
- ALLOWS FOR LOCAL TREATMENT IN THE SETTING OF INFECTION OR EXPOSURE - Intervene without removing the implant in most cases; minimize the likelihood of additional procedures and the resulting soft tissue loss.7,11
- RESISTANT TO ADHESION FORMATION - Helps prevent adhesion of the visceral contents to the graft, minimizing complications such as bowel obstructions and fistula formations; allows for simpler future surgeries in the abdominal area; minimize post-operative pain.3,8
- REDUCES COSTLY COMPLICATIONS - Demonstrated to have substantially fewer complications than synthetics, including infection, adhesion formation, erosion, extrusion, fistula formation, and recurrence; may reduce length of hospital stay and associated medical costs.7,9,12
- EXCELLENT HANDLING PROPERTIES - Retains tensile characteristics to ensure excellent handling for intraoperative manipulation, sizing, shaping and suturing.1
- VERSATILE ACELLULAR MATRIX - Exhibits remarkable versatility to convert into functional tissues that provide structural support like gingiva and fascia; supports restoration of structure, function and physiology.9,10
- SAFE - Screened and tested according to FDA regulations, American Association of Tissue Banks Standards, and appropriate state regulations.
Before use, physicians should review all risk information, which can be found in the "Instructions for Use" attached to the packaging of each AlloDerm graft.
References:
- Choe JM, et al. Autologous, cadaveric and synthetic materials used in sling surgery: Comparative biomechanical analysis. Urology. 2001; 58(3): 482-486.
- Barber FA, et al. Tendon augmentation grafts: Biomechanical failure loads and failure patterns. Arthroscopy. 2006; 22(5): 534-538.
- Menon NG, et al. Revascularization of human acellular dermis in full-thickness abdominal wall reconstruction in the rabbit model. Ann Plast Surg. 2003; 50: 523-527.
- Patton JH Jr, et al. Use of human acellular dermal matrix in complex and contaminated abdominal wall reconstructions Am J Surg. 2007 Mar;193(3):360-3; discussion 363.
- Diaz JJ Jr, et al. Acellular Dermal Allograft for Ventral Hernia Repair in the Compromised Surgical Field. Am Surg. 2006 Dec;72(12):1181-1188
- Kim H, et al. Acellular dermal matrix in the management of high-risk abdominal wall defects. Am J Surg. 2006 Dec; 192(6): 705-9.
- Butler CE, et al. Pelvic, Abdominal, and Chest Wall Reconstruction with AlloDerm in Patients at Increased Risk for Mesh-Related Complications. Plast Reconstr Surg. 2005 Oct;116(5):1263-1275; discussion 1276-1277.
- Butler CE, et al. Reduction of adhesions with composite AlloDerm/polypropylene mesh implants for abdominal wall reconstruction. Plast Reconstr Surg. 2004; 114(2): 464-473.
- Buinewicz B, et al. Acellular cadaveric dermis (AlloDerm): A new alternative for abdominal hernia repair. Ann Plast Surg. 2004; 52(2): 188-194.
- Glasberg SB, et al. Use of Regenerative Human Acellular Tissue (AlloDerm) to Reconstruct the Abdominal Wall following Pedicle TRAM Flap Breast Reconstruction Surgery. Plast Reconstr Surg. 2006 July; 118(1): 8-15.
- Kish KJ, et al. Acellular Dermal Matrix (AlloDerm): New Material in the Repair of Stoma Site Hernias. Am Surg. 2005 Dec;71(12): 1047-50
- Kaleya RN, et al. Use of a global economic model to analyze the cost-benefit of AlloDerm in ventral hernia repair. LifeCell Clinical Monograph Series. 2005.
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