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Tissue Regeneration using a Human Acellular Tissue Matrix - A Histological Perspective.
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LifeCell Clinical Monograph Series, 2005.
John R. Harper, Ph.D.
Vice President, Clinical Sciences
Chairman, Scientific Review Board
LifeCell Corporation
Abstract:
The long term goal of soft tissue regeneration is to provide surgeons with the tools for restoring structure, function and physiology with a biological repair that is dynamic and metabolizes with the patient. Since the adult is incapable of healing through regeneration, the process of reparative healing leads to the formation of scar tissue, which is pathological in many aspects. If a regenerative tissue matrix, such as AlloDerm®, is used as a scaffold to organize the healing process, the body has the capacity to regenerate functional tissue. Placing a dermal regenerative matrix in various functional sites within the body leads to revascularization, cellular repopulation and transition of the scaffold to the appropriate tissue for the surgery site. A spectrum of clinical biopsies have been analyzed from explants up to 2 years after grafting into the breast and abdominal wall and found to be fully viable and exhibiting characteristics of the original tissue that was being replaced. The histological review in this monograph suggests that AlloDerm does not remain a dermis over time, but rather transitions to the appropriate tissue. |
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