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Tissue Regeneration

Intrinsic tissue regeneration in the body

Intrinsic tissue regeneration is the body’s regular maintenance cycle in which millions of tissue cells constantly undergo remodeling and restoration. It begins with circulating mesenchymal stem cells originating from bone marrow. Biochemical signals draw the stem cells to sites where growth factors have created an environment for regeneration.

Scar tissue vs regenerated tissue

Scar tissue is different from regenerated tissue. When an injury occurs, the body’s first reaction is hemostasis when fibrin and inflammatory cytokines form a blood clot or provisional scaffold. More inflammatory cells arrive, remodeling the clot into scar tissue. Collagen in scar tissue is abnormally aligned and has little elastin. Unlike regenerated tissue, scar tissue is different—and less perfect— than the surrounding tissue it replaces. Rather than triggering a scarring response, AlloDerm® Regenerative Tissue Matrix allows nature to follow its own regenerative process—restoring tissue to its original structural, functional, and physiological condition.

Tissue regeneration and AlloDerm® Tissue Matrix

AlloDerm® Tissue Matrix is an ideal biological framework to harness nature’s own regenerative healing process.

During the regeneration process, AlloDerm® Tissue Matrix transitions into tissue in four stages:

  1. The circulating stem cells target damaged tissue
  2. In the target area, these cells deposit and adhere to the matrix
  3. Next, the cells differentiate into tissue-specific cell types
  4. Finally, the differentiated cells elaborate the new matrix to
    regenerate tissue
Supports rapid revascularization and repopulation: The vascular architecture is endothelialized, and host stem cells migrate and bind specifically to protein components of the matrix.
Supports remodeling to the patient’s own tissue: The matrix is now fully revascularized, repopulated and integrated into the host tissue. Proteins undergo normal breakdown and regeneration.
Supports transition to specific host tissue: Host cells continue to respond to the local environment, and the matrix transitions into the tissue it is replacing at the site of the transplant.

AlloDerm® Tissue Matrix transitioned into host tissue: This histology of a clinical biopsy taken eight months post-operatively illistrates that, when placed in the abdominal wall next to native fascia, AlloDerm® Tissue Matrix rapidly revascularized and repopulated with patient fibroblast cells, then transitioned into fascia-like tissue.

Source: Buinewicz B, Colony LH, Smith RJ. The Use of Human Acellular Tissue Matrix in Abdominal Wall Reconstruction - A Clinical Perspective. LifeCell Clinical Monograph Series, 2003.

Before use, physicians should review all risk information and essential prescribing information which can be found in the AlloDerm® Regenerative Tissue Matrix Instructions for Use.